Active Caspase-3 Monoclonal Antibody(5E1)
簡(jiǎn)要描述:Active Caspase-3 Monoclonal Antibody(5E1)宿主: Monoclonal, Mouse反應(yīng)性: Human;Mouse;Rat;Chicken應(yīng)用: IF;WB;IP;IHC
產(chǎn)品型號(hào): YP-Ab-00121
所屬分類(lèi):單克隆抗體
更新時(shí)間:2024-10-31
詳細(xì)說(shuō)明:
Active Caspase-3 Monoclonal Antibody(5E1)
抗體,也叫免疫球蛋白(Ig),是一種能特異性結(jié)合抗原的糖蛋白,而抗原是在易感染動(dòng)物體內(nèi)引發(fā)抗體產(chǎn)生的物質(zhì)。在體內(nèi),抗體是由于外源性分子的侵襲而產(chǎn)生的??贵w以一個(gè)或者多個(gè)Y字形單體存在,每個(gè)Y字形單體由4條多肽鏈組成,包含兩條相同的重鏈和兩條相同的輕鏈。輕鏈和重鏈?zhǔn)歉鶕?jù)它們的分子量大小來(lái)命名的。Y字形結(jié)構(gòu)的頂端是可變區(qū),為抗原結(jié)合部位。任何一個(gè)抗體的輕鏈都可以分為κ或λ型(基于小分子多肽結(jié)構(gòu)上的差異),每一個(gè)抗體的重鏈則決定了它的類(lèi)或型。
產(chǎn)品詳情
The antibody detects endogenous cleaved Caspase-3 protein p17 isoform.
免疫原詳細(xì)信息
Recombinant Protein of Active Caspase-3
相關(guān)試劑
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
背景
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008].
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